Base documentaire
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Cholesterolemia in colorectal cancer.
HEPATO GASTROENTEROLOGY, vol. 45, n° 23, 1998, pages 1531-1534, 12 réf., ISSN 0172-6390, DEU
MANOUKIAN FORONES (N.), FALCAO (J.B.), MATTOS (D.), BARONE (B.)
Clinical Gastroenterology. Oncology Division. Universidade Federal de Sao Paulo Unifesp-Escola Paulista de Medicina. BRA, Surgical Gastroenterology Division. Universidade Federal de Sao Paulo Unifesp-Escola Paulista de Medicina. BRA
BACKGROUND/AIMS
Colorectal cancer incidence is higher in developed countries.
High fat intake is one of the risk factors.
However, many studies observed lower cholesterol serum levels on diagnosis of colorectal cancer.
The aim of this assay was to study the serum cholesterol levels in patients with colorectal cancer and compare these values with individuals of the same age and sex.
METHODOLOGY
Cholesterol serum levels of 85 patients with colorecectal cancer were determined.
Each of the patients with colorectal cancer were matched with an individual without cancer of the same age and sex.
Total cholesterol concentrations were determined using an enzymatic colorimetric method.
RESULTS
The mean serum of cholesterol was 183,4 for the colorectal group and 209.7 for the control group.
This difference was statistically significant.
This difference was more evident in patients with colon cancer and older than 60 years of age.
There was no difference between the different Dukes'stage.
CONCLUSIONS
Our study suggest an association between low blood cholesterol and colorectal cancer.
We believe that the lower level of cholesterol observed in these patients is a consequence between the difference of colorectal carcinogenesis.
Mots-clés BDSP : Rectum, Facteur risque, Cholestérol, Etude comparée, Homme, Cancer, Appareil digestif [pathologie], Intestin [pathologie], Nutrition, Colon
Mots-clés Pascal : Carcinome, Côlon, Rectum, Facteur risque, Régime alimentaire enrichi, Graisse, Taux concentration, Cholestérol, Etude comparative, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Nutrition
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Risk factor, Supplemented diet, Grease, Concentration factor, Cholesterol, Comparative study, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Nutrition
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