Chronic adequate alcohol intake induces an « adaptive cytoprotection », mediated by endogenous release of prostaglandins and increased activity of gastric antioxidants, that reduces the mucosal damage caused by higher ethanol concentrations.
The aim of our study was to verify the presence of a protection against Helicobacter pylori infection, induced by adequate alcohol consumption, with or without cigarette smoking.
We studied 303 consecutive dyspeptic patients, who underwent gastroscopy for the first time.
The patients were allocated to four groups : A) 57 with adequate alcohol consumption ; B) 88 smokers pts ; C) 64 smokers pts with adequate alcohol consumption ; D) 93 non-smokers and teetotalers.
H. pylori infection was found in 32 pts of group A (56.14%), 67 of group B (77.13%), 46 of group C (71.87%) and 61 of group D (65.69%). There was a statistical significant difference in H. pylori-positivity only between group A and group B (p=0.019).
Even if we noted a statistical difference only between group A and B, however the lower prevalence of H. pylori infection in group A than in other groups suggests a protective mechanism of adequate alcohol consumption, mediated by « adaptive cytoprotection », which reduces the risk of H. pylori infection.
Mots-clés Pascal : Gastrite, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Diminution, Risque, Prise boisson, Ethanol, Quantité, Faible, Effet biologique, Tabagisme, Prévention, Homme, Appareil digestif pathologie, Estomac pathologie
Mots-clés Pascal anglais : Gastritis, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Decrease, Risk, Drinking, Ethanol, Quantity, Low, Biological effect, Tobacco smoking, Prevention, Human, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0016610
Code Inist : 002B26F. Création : 31/05/1999.