Objective The etiology of Wegener's granulomatosis (WG) remains unknown.
The predominant involvement of the airways and the presence of neutrophilic alveolitis at disease onset have led us to postulate that an inhaled agent may trigger the onset of WG.
This study is designed to analyze differences in self-reported environmental exposures between patients with WG and various control populations.
Methods We conducted a standard interviewer-administered questionnaire case controlled survey of 101 patients with WG, 54 healthy controls, 24 patients with sarcoidosis or idiopathic pulmonary fibrosis, and 45 patients with various inflammatory rheumatologic diseases.
We assessed environmental exposures for one year prior to the onset of symptoms or prior to the interview date for healthy controls.
Results Seasonal differences in the onset of WG were not apparent.
More than 75% of the patients in all groups noted remarkable environmental exposure to inhaled substances (fumes or particulate matter), within one year prior to disease onset for WG and other diseases or prior to the interview date for healthy controls.
Differences between WG and control groups were apparent in several categories of exposure. (...)
Mots-clés Pascal : Granulomatose Wegener, Pathogénie, Facteur milieu, Epidémiologie, Facteur risque, Inhalation, Relation hôte agent, Evaluation, Questionnaire, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Vascularite, Maladie système
Mots-clés Pascal anglais : Wegener granulomatosis, Pathogenesis, Environmental factor, Epidemiology, Risk factor, Inhalation, Host agent relation, Evaluation, Questionnaire, Human, Cardiovascular disease, Vascular disease, Vasculitis, Systemic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0016147
Code Inist : 002B07. Création : 31/05/1999.