INA-6 : Meeting of the International Neurotoxicology Association. Szeged, HUN, 1997/06/29.
A questionnaire-based case-control study was carried out on 86 patients with neurologist-confirmed idiopathic Parkinson's disease (PD) and 86 controls similar in sex and age.
The control group was recruited in outpatient specialist centers of the same University Hospital (glaucoma, psoriasis vulgaris, essential arterial hypertension and renal diseases).
Exposure was defined as occupational or residential contact with a given factor for at least 10 consecutive years prior to the onset of PD.
Smoking habits were defined by exclusion of those subjects who never smoked.
The following risk factors were identified : cranial trauma (OR : 2.88 ; 95% CI : 0.98-8.49), well water use (OR : 2.78 ; 95% CI : 1.46-5.28) and occupational exposure to industrial chemicals (OR : 2.13 ; 95% CI : 1.16-3.91).
Among industrial chemicals, only organic solvents were identified as significant risk factors for PD (O.R. : 2.78,95% C.I. : 1.23-6.26).
Whereas no exposure to neurotoxic metals occurred among controls, making the assessment of the O.R. impossible, exposure pesticides and herbicides was similar in the two groups (O.R. : 1.15 ; 95% C.I. : 0.56-2-36).
Smoking habits was negatively associated with PD (OR : 0.41 ; 95% CI : 0.22-0.75), confirming the « protective » role of tobacco smoking suggested by many studies.
As a whole, these results support the role of environmental factors in the etiology of PD.
Mots-clés Pascal : Composé chimique, Environnement, Italie, Europe, Parkinson maladie, Solvant organique, Homme, Facteur risque, Epidémiologie, Activité professionnelle, Exposition professionnelle, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Chemical compound, Environment, Italy, Europe, Parkinson disease, Organic solvent, Human, Risk factor, Epidemiology, Professional activity, Occupational exposure, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0009181
Code Inist : 002B03L04. Création : 31/05/1999.