logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Autoantibodies against calpastatin in sera from patients with systemic sclerosis.

    Article - En anglais

    Objective

    To determine the prevalence and clinical correlation of anti-calpastatin antibodies in patients with systemic sclerosis (SSc).

    Methods

    Serum samples from patients with limited cutaneous SSc (lSSc ; n=36), diffuse cutaneous SSc (dSSc ; n=27), and healthy control subjects (n=29) were examined by an ELISA using human recombinant calpastatin as antigens.

    Results

    IgG anti-calpastatin antibodies were positive in 15 (24%) of 63 patients with SSc, which was similar to the frequency of IgM anti-calpastatin antibody positivity (14/63,22%). The presence of anticentromere antibodies was associated with the presence of IgG and/or IgM anti-calpastatin antibodies.

    The patients with SSc positive for IgG anti-calpastatin antibodies had significantly higher erythrocyte sedimentation rates (ESR) compared with those negative for IgG anti-calpastatin antibodies.

    Furthermore, the levels of IgG anti-calpastatin antibodies correlated positively with the levels of ESR.

    The patients with dSSc positive for IgM anti-calpastatin antibodies had significantly higher frequency of inflammatory joint and muscle involvement compared with those negative for IgM anti-calpastatin antibodies.

    Four (80%) of 5 patients with dSSc with both joint and muscle involvement produced IgM anti-calpastatin antibodies.

    Conclusion

    The presence of anti-calpastatin antibodies may be a clue to mechanisms of the inflammatory change occurring in SSc. (...)

    Mots-clés Pascal : Sclérodermie, Pathogénie, Symptomatologie, Epidémiologie, Prévalence, Anticorps, Autoanticorps, Sérum, Analyse corrélation, Homme, Technique ELISA, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Calpastatine

    Mots-clés Pascal anglais : Scleroderma, Pathogenesis, Symptomatology, Epidemiology, Prevalence, Antibody, Autoantibody, Serum, Correlation analysis, Human, ELISA assay, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0007801

    Code Inist : 002B07. Création : 31/05/1999.