Autoantibodies against calpastatin in sera from patients with systemic sclerosis.
To determine the prevalence and clinical correlation of anti-calpastatin antibodies in patients with systemic sclerosis (SSc).
Serum samples from patients with limited cutaneous SSc (lSSc ; n=36), diffuse cutaneous SSc (dSSc ; n=27), and healthy control subjects (n=29) were examined by an ELISA using human recombinant calpastatin as antigens.
IgG anti-calpastatin antibodies were positive in 15 (24%) of 63 patients with SSc, which was similar to the frequency of IgM anti-calpastatin antibody positivity (14/63,22%). The presence of anticentromere antibodies was associated with the presence of IgG and/or IgM anti-calpastatin antibodies.
The patients with SSc positive for IgG anti-calpastatin antibodies had significantly higher erythrocyte sedimentation rates (ESR) compared with those negative for IgG anti-calpastatin antibodies.
Furthermore, the levels of IgG anti-calpastatin antibodies correlated positively with the levels of ESR.
The patients with dSSc positive for IgM anti-calpastatin antibodies had significantly higher frequency of inflammatory joint and muscle involvement compared with those negative for IgM anti-calpastatin antibodies.
Four (80%) of 5 patients with dSSc with both joint and muscle involvement produced IgM anti-calpastatin antibodies.
The presence of anti-calpastatin antibodies may be a clue to mechanisms of the inflammatory change occurring in SSc. (...)
Mots-clés Pascal : Sclérodermie, Pathogénie, Symptomatologie, Epidémiologie, Prévalence, Anticorps, Autoanticorps, Sérum, Analyse corrélation, Homme, Technique ELISA, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Calpastatine
Mots-clés Pascal anglais : Scleroderma, Pathogenesis, Symptomatology, Epidemiology, Prevalence, Antibody, Autoantibody, Serum, Correlation analysis, Human, ELISA assay, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0007801
Code Inist : 002B07. Création : 31/05/1999.