Bacterial enteropathogens, the major cause of travelers'diarrhea, are customarily treated with antibacterial drugs.
Rifaximin, a nonabsorbed antimicrobial was examined as treatment for travelers'diarrhea.
A randomized, prospective, double-blind clinical trial was carried out in 72 US adults in Mexico.
Patients with acute diarrhea received one of three doses of rifaximin (200,400 and 600 mg t.i.d.) or trimethoprim/sulfamethoxazole (TMP/SMX, 160 mg/800 mg b.i.d.) for 5 days.
Results were compared with data from 2 placebo-treated historical control populations.
The shortest duration of treated diarrhea was seen in the group receiving 200 mg rifaximin t.i. d (NS).
Clinical failure to respond to treatment occurred in 6 of 55 (11%) rifaximin-treated subjects versus 5 of 17 (29%) of TMP/SMX-treated subjects (NS).
Sixteen of twenty (80%) of the enteropathogens isolated from the rifaximin-treated subjects and 7 of 7 (100%) from the TMP/SMX group were eradicated by treatment (NS).
Sixteen of twenty-four (67%) enteropathogens identified were susceptible to TMP and all 24 were inhibited by <= 50 mug/ml of rifaximin.
Rifaximin reduced the number of unformed stools passed during the first 24 h of treatment when compared with 2 control placebo groups (3.3 versus 5.1 ; p=0.008 and 0.0001) and led to a reduced duration of post-enrollment diarrhea (mean values of 43. 1 versus 68.1 and 81.9 h ; p=0.001). (...)
Mots-clés Pascal : Diarrhée du voyageur, Randomisation, Essai thérapeutique contrôlé, Rifaximine, Chimiothérapie, Etude comparative, Triméthoprime, Sulfaméthoxazole, Pharmacocinétique, Facteur sécurité, Homme, Mexique, Amérique Centrale, Amérique, Efficacité traitement, Appareil digestif pathologie, Intestin pathologie, Antituberculeux, Antiinfectieux
Mots-clés Pascal anglais : Traveler disease, Randomization, Controlled therapeutic trial, Rifaximin, Chemotherapy, Comparative study, Trimethoprim, Sulfamethoxazole, Pharmacokinetics, Safety factor, Human, Mexico, Central America, America, Treatment efficiency, Digestive diseases, Intestinal disease, Antituberculous agent, Antiinfectious
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0007733
Code Inist : 002B02H. Création : 31/05/1999.