To compare treatment completion rates at 8 and 12 months after treatment initiation for patients with active TB treated with either directly observed therapy (DOT) or self-administered therapy (SAT).
Retrospective comparison study of DOT and SAT concurrent patient cohorts.
Urban Tuberculosis Control Program within a Department of Public Health.
Three hundred nineteen patients confirmed to have active TB between July 1,1994, and June 30,1995, who began outpatient drug therapy.
Patients and/or their physicians chose to receive their anti-TB drug therapy by DOT (n=113) or SAT (n=206) and were assessed for treatment completion at prospectively determined times, 8 and 12 months.
Proportions of patients who completed treatment at 8 and 12 months without crossing over to the other group were compared.
At 8 months, 52% of DOT and 35% of SAT patients had completed treatment (relative superiority of DOT, 49% ; p=0.003).
At 12 months, completion rates were 70% for DOT patients and 53% for SAT patients (relative superiority of DOT, 30% ; p=0.006).
In our setting, patients receiving DOT were much more likely to complete treatment earlier than those receiving SAT.
Even with DOT, only 52% of patients had completed treatment by 8 months.
Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Etats Unis, Amérique du Nord, Amérique, Antituberculeux, Traitement, Chimiothérapie, Homme, Autoadministration, Observance médicamenteuse, Exploration, Surveillance, Efficacité traitement, Antibiotique
Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, United States, North America, America, Antituberculous agent, Treatment, Chemotherapy, Human, Self administration, Drug compliance, Exploration, Surveillance, Treatment efficiency, Antibiotic
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0006656
Code Inist : 002B02S02. Création : 31/05/1999.