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  1. A controlled comparison of directly observed therapy vs self-administered therapy for active tuberculosis in the Urban United States.

    Article - En anglais

    Study objectives 

    To compare treatment completion rates at 8 and 12 months after treatment initiation for patients with active TB treated with either directly observed therapy (DOT) or self-administered therapy (SAT).


    Retrospective comparison study of DOT and SAT concurrent patient cohorts.


    Urban Tuberculosis Control Program within a Department of Public Health.


    Three hundred nineteen patients confirmed to have active TB between July 1,1994, and June 30,1995, who began outpatient drug therapy.


    Patients and/or their physicians chose to receive their anti-TB drug therapy by DOT (n=113) or SAT (n=206) and were assessed for treatment completion at prospectively determined times, 8 and 12 months.

    Measurements and results 

    Proportions of patients who completed treatment at 8 and 12 months without crossing over to the other group were compared.

    At 8 months, 52% of DOT and 35% of SAT patients had completed treatment (relative superiority of DOT, 49% ; p=0.003).

    At 12 months, completion rates were 70% for DOT patients and 53% for SAT patients (relative superiority of DOT, 30% ; p=0.006).


    In our setting, patients receiving DOT were much more likely to complete treatment earlier than those receiving SAT.

    Even with DOT, only 52% of patients had completed treatment by 8 months.

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Etats Unis, Amérique du Nord, Amérique, Antituberculeux, Traitement, Chimiothérapie, Homme, Autoadministration, Observance médicamenteuse, Exploration, Surveillance, Efficacité traitement, Antibiotique

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, United States, North America, America, Antituberculous agent, Treatment, Chemotherapy, Human, Self administration, Drug compliance, Exploration, Surveillance, Treatment efficiency, Antibiotic

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0006656

    Code Inist : 002B02S02. Création : 31/05/1999.