Background The need for protecting agents against degenerative processes of the body has been proposed to be especially high in elderly people.
In order to evaluate the prognostic value of various biochemical factors in ageing the associations of blood concentrations of several vitamins, mineral elements and some other suggested risk factors with vascular and non-vascular mortality were studied in an elderly population.
Methods A large health survey with complete clinical evaluation was carried out in the City of Turku in 1982-1983.
A random sample of 344 community-living elderly individuals aged 65 years or older, stratified into four age groups, was studied.
During the 13 years follow-up 225 subjects had died.
Calcium, magnesium, copper, ceruloplasmin, zinc, selenium, iron, ferritin, transferrin, alpha-tocopherol, retinol, folate, vitamin B12, malondialdehyde, orosomucoid and insulin levels were analysed from the blood specimens.
The relations between the compounds measured and relative mortality risks during the 13-year follow-up were analysed by Cox proportional hazards model adjusting for other known risk factors.
Results and High concentrations of serum copper, orosomucoid and insulin were associated Conclusions with increased risk of vascular mortality.
The relative risks within the subjects of the highest tertile of serum concentrations were 2.2 for copper, 1.8 for orosomucoid, and 1.8 for insulin when adjusted for many confounding risk factors. (...)
Mots-clés Pascal : Mortalité, Vitamine, Minéral, Marqueur biologique, Inflammation, Plasma sanguin, Epidémiologie, Facteur risque, Personne âgée, Homme, Finlande, Europe
Mots-clés Pascal anglais : Mortality, Vitamin, Minerals, Biological marker, Inflammation, Blood plasma, Epidemiology, Risk factor, Elderly, Human, Finland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0004652
Code Inist : 002B30A01A2. Création : 31/05/1999.