Objectives-To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufacture of 2,4,5-trichlorophenate and its derivatives.
The reference group consisted of people with no occupational exposure to phenoxy herbicides who lived within the communities of the workers.
Data from a total of 259 workers and 243 unexposed referents were included in the analysis of immune function.
Laboratory tests for immune status included enumeration of circulating leukocyte and lymphocyte populations, proliferative responses of circulating lymphocytes to mitogens and antigens, and serum concentrations of the major immunoglobulins and complement factor C3.
The workers had substantial exposure to substances contaminated with TCDD, as indicated by a lipid adjusted mean serum TCDD concentration of 229 ppt compared with a mean of 6 ppt in the unexposed referents.
Workers were divided into categories based on their serum TCDD concentration.
For all categories except the lowest, with values of serum TCDD comparable with the unexposed referents, there were increased odds of having lower counts of CD26 cells (activated T cells) (odds ratio (OR) 1.0,95% confidence interval (95% CI) 0.5 to 1.8 for TCDD<20 ppt ; OR 1.6,95% CI 0.8 to 3. (...)
Mots-clés Pascal : Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Industrie chimique, Homme, Exposition professionnelle, Médecine travail, Etude cohorte, Toxicité, Système immunitaire, Marqueur biologique, Surveillance biologique, Liquide biologique, Sang, Lymphocyte T, Analyse statistique, Corrélation, Antigène CD26
Mots-clés Pascal anglais : Chemical industry, Human, Occupational exposure, Occupational medicine, Cohort study, Toxicity, Immune system, Biological marker, Biological monitoring, Biological fluid, Blood, T-Lymphocyte, Statistical analysis, Correlation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0004184
Code Inist : 002B03L06. Création : 31/05/1999.