The presence of circulating « flower cells » and a low prevalence of antibody to Tax regulatory protein of human T-lymphotropic virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL).
To examine the predictability of levels of HTLV-I antibodies and of flower cell-like abnormal lymphocytes (Ably) for the risk of ATL among asymptomatic HTLV-I carriers, we prospectively evaluated the levels of viral markers of five HTLV-I carriers who developed ATL and 38 age-sex-and screen-matched HTLV-I-positive controls in the Miyazaki Cohort Study.
After accounting for matching factors, Ably level was slightly, but not significantly, higher among cases than among controls (P=13).
Anti-HTLV-I (odds ratio [OR]=1.6 per twofold dilution ; 95% confidence interval [CI] 0.94,3.8) was associated with ATL diagnosis, but antibody to Tax regulatory protein (anti-Tax) was not (OR=0.78 ; 95% Cl 0.26,1.7).
Anti-Tax level was low for all ATL cases for up to 10 years preceding their diagnosis, independent of the level of anti-HTLV-I titer.
HTLV-I carriers with a higher anti-HTLV-I titer and a lower anti-Tax reactivity may be at greatest risk of ATL.
Mots-clés Pascal : Leucémie cellule T adulte, Virose, Infection, Facteur risque, Asymptomatique, Marqueur biologique, Anticorps, Lymphocyte, Morphologie, Epidémiologie, Japon, Asie, Etude cas témoin, Adulte, Homme, Virus HTLV1, Retroviridae, Virus, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Adult T cell leukemia, Viral disease, Infection, Risk factor, Asymptomatic, Biological marker, Antibody, Lymphocyte, Morphology, Epidemiology, Japan, Asia, Case control study, Adult, Human, HTLV-I virus, Retroviridae, Virus, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0002905
Code Inist : 002B19B. Création : 31/05/1999.