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  1. Benign anal lesions, inflammatory bowel disease and risk for high-risk human papillomavirus-positive and - negative anal carcinoma.

    Article - En anglais

    A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and - negative anal cancers.

    As part of a population-based case-control study in Denmark and Sweden, we interviewed 417 case patients (93 men and 324 women) diagnosed during the period 1991-94 with invasive or in situ anal cancer, 534 patients with adenocarcinoma of the rectum and 554 population controls.

    Anal cancer specimens (n=388) were tested for HPV by the polymerase chain reaction.

    Excluding the 5 years immediately before diagnosis, men, but not women, with anal cancer reported a history of haemorrhoids [multivariate odds ratio (OR) 1.8 ; 95% confidence interval (Cl) 1.04-3.2] and unspecific anal irritation (OR 4.5 ; Cl 2.3-8.7) significantly more often than controls.

    Women with anal cancer did not report a history of benign anal lesions other than anal abscess to any greater extent than controls, but they had used anal suppositories more often (OR 1.5 ; Cl 1.1-2.0).

    Patients with hrHPV in anal cancer tissue (84%) and those without (16%) reported similar histories of most benign anal lesions, but anal fissure or fistula was more common among hrHPV-positive cases.

    Ulcerative colitis and Crohn's disease, reported by<1% of study participants, were not associated with anal cancer risk. (...)

    Mots-clés Pascal : Carcinome, Anus, Facteur risque, Epidémiologie, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Fissure anale, Fistule, Anorectal, Rectocolite ulcérohémorragique, Entérite Crohn, Hémorroïde, Etude cas témoin, Suède, Europe, Danemark, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Anorectale pathologie, Maladie inflammatoire

    Mots-clés Pascal anglais : Carcinoma, Anus, Risk factor, Epidemiology, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Anal fissure, Fistula, Anorectal, Ulcerative colitis, Crohn disease, Hemorrhoid, Case control study, Sweden, Europe, Denmark, Human, Malignant tumor, Digestive diseases, Intestinal disease, Anorectal disease, Inflammatory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0002115

    Code Inist : 002B13B01. Création : 31/05/1999.