Hormonal and reproductive influences and risk of melanoma in women.
Background Evidence linking female hormones to the development of malignant melanoma has been contradictory.
The purpose of this study was to examine the risk of melanoma in relation to exogenous and endogenous hormonal variables in women, including oral contraceptives, replacement oestrogens, pregnancy, and menopause.
Methods Hormonal and reproductive factors were evaluated using data from a personal-interview population-based case-control study of melanoma in women conducted in Connecticut during 1987-1989.
Caucasian female incident invasive melanoma cases (n=308) were confirmed by standardized histopathological review.
Caucasian female controls (n=233) were selected by random digit dialling and frequency-matched on age.
Data were analysed using multivariate logistic regression.
Results Ever being pregnant, age at first pregnancy, current use of replacement oestrogens, ever use of oral contraceptives, duration of use of oral contraceptives, and age at first use of oral contraceptives were not associated with melanoma.
Among other variables, cases were more than twice as likely as controls to report a single pregnancy lasting>6 months, but this association lacked a dose-response relationship.
Menopause and body mass index were not independently associated with risk of melanoma.
However, this analysis did suggest that menopause and body mass index may be interactive risk factors. (...)
Mots-clés Pascal : Mélanome malin, Ménopause, Gestation, Oestrogène, Progestérone, Contraception, Voie orale, Epidémiologie, Facteur risque, Incidence, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Hormone
Mots-clés Pascal anglais : Malignant melanoma, Menopause, Pregnancy, Estrogen, Progesterone, Contraception, Oral administration, Epidemiology, Risk factor, Incidence, Human, Female, United States, North America, America, Malignant tumor, Hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0001989
Code Inist : 002B08A. Création : 31/05/1999.