Background A cross-sectional survey was conducted between April 1995 and March 1996 to investigate arsenic-associated skin lesions of keratosis and hyperpigmentation in West Bengal, India, and to determine their relationship to arsenic water levels.
Methods In all, 7683 participants were examined and interviewed, and the arsenic levels in their drinking water measured.
Results Although water concentrations ranged up to 3400 mug/l of arsenic, over 80% of participants were consuming water containing<500 mug/l. The age-adjusted prevalence of keratosis was strongly related to water arsenic levels, rising from zero in the lowest exposure level (<50 mug/l) to 8.3 per 100 for females drinking water containing>800 mug/l, and increasing from 0.2 per 100 in the lowest exposure category to 10.7 per 100 for males in the highest exposure level (>=800 mug/l).
However, 12 cases with keratosis (2 females and 10 males) were drinking water containing<100 mug/l of arsenic.
Findings were similar for hyperpigmentation, with strong dose-response relationships.
Among those with hyperpigmentation, 29 cases were exposed to drinking water containing<100 mug/l. Calculation by dose per body weight showed that men had roughly two to three times the prevalence of both keratosis and hyperpigmentation compared to women apparently ingesting the same dose of arsenic from drinking water.
Subjects who were below 80% of the standard body weight for their age and sex had a 1. (...)
Mots-clés Pascal : Eau alimentation, Eau potable, Arsenic, Kératose, Hyperpigmentation, Epidémiologie, Prévalence, Facteur risque, Homme, Santé et environnement, Inde, Asie, Toxicité, Métal lourd, Peau pathologie, Trouble pigmentation
Mots-clés Pascal anglais : Feed water, Drinking water, Arsenic, Keratosis, Hypermelanosis, Epidemiology, Prevalence, Risk factor, Human, Health and environment, India, Asia, Toxicity, Heavy metal, Skin disease, Pigmentation disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0001877
Code Inist : 002B03L05. Création : 31/05/1999.