Background An inconsistent relationship has been reported between insulin and hypertension incidence.
Free fatty acids are related to insulin-resistance and may have a direct effect on hypertension.
We examined the effect of free fatty acids on hypertension incidence, taking into account other abnormalities of the insulin-resistance syndrome.
Methods In all, 2968 non-hypertensive and non-diabetic Caucasian men were followed for 3 years.
Hypertension incidence was defined as systolic blood pressure (SBP) >=160 mmHg or diastolic blood pressure (DBP) >=95 mmHg or drug treatment for hypertension.
Results Free fatty acid elevation was a highly significant risk factor for hypertension when controlled for age, family history of hypertension, alcohol consumption, body mass index, iliac circumference and weight change.
Further controlling for SBP, heart rate and fasting insulin and glucose did not decrease its predictive power (hazard rate ratio [RR]=1.58,95% confidence interval [CI] : 1.30-1.91 comparing the 90th to the 10th percentiles at fasting ; RR=1.54,95% CI : 1.33-1.79 at 2 h).
In a forward stepwise model controlled for age, family history of hypertension, alcohol consumption and SBP, the selected variables explaining the occurrence of hypertension were, in order, weight change, 2-h free fatty acids, iliac circumference and fasting free fatty acids, whereas body mass index, heart rate, insulin, glucose and other lipids did not enter into the model. (...)
Mots-clés Pascal : Hypertension artérielle, Acide gras libre, Lipide, Plasma sanguin, Epidémiologie, Facteur risque, Incidence, Homme, Mâle, France, Europe, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Hypertension, Free fatty acid, Lipids, Blood plasma, Epidemiology, Risk factor, Incidence, Human, Male, France, Europe, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0001874
Code Inist : 002B12B05B. Création : 31/05/1999.