Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico.
We have studied hepatic function in individuals chronically exposed to arsenic (As) via drinking water in Region Lagunera, Mexico.
We studied 51 individuals living in three villages exposed to As in water.
Nazareno (0.014 mgAs/l), Santa Ana (0.1 mgAs/l) and Benito Juárez (0.3 mgAs/l).
We determined the serum activity of aspartate aminotransferase (SAT) and alanine aminotransferase (ALT) as indicators of hepatocellular injury and that of gamma-glutamyl-transpeptidase (GGT) and alkaline phosphatase (ALP) as indicators of cholestasic injury.
Serum bilirubin was used as an indicator of organic conjugated anion transport.
Total proteins, albumin and globulin fraction in serum were used as indicators of biosynthetic liver capacity.
The main findings of this study were the predominantly conjugated hyperbilirubinemia and increased serum ALP activity which were related to the concentration of total arsenic (TAs) in urine, suggesting the presence of cholestasis in As-exposed individuals.
No significant changes were observed in the other parameters studied.
Mots-clés Pascal : Toxicité, Arsenic, Chronique, Ingestion, Eau potable, Epidémiologie, Mexique, Amérique Centrale, Amérique, Homme, Appareil digestif pathologie, Foie, Hyperbilirubinémie, Voie biliaire pathologie, Activité enzymatique, Alkaline phosphatase, Phosphoric monoester hydrolases, Esterases, Hydrolases, Enzyme, Liquide biologique, Urine
Mots-clés Pascal anglais : Toxicity, Arsenic, Chronic, Ingestion, Drinking water, Epidemiology, Mexico, Central America, America, Human, Digestive diseases, Liver, Hyperbilirubinemia, Biliary tract disease, Enzymatic activity, Alkaline phosphatase, Phosphoric monoester hydrolases, Esterases, Hydrolases, Enzyme, Biological fluid, Urine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0536811
Code Inist : 002B03L05. Création : 23/03/1999.