Objectives-To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously.
Study design-Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulised salbutamol.
The placebo and treatment groups of children were similar at baseline.
The 48 children in the aminophylline group had a greater improvement in spirometry at six hours and a higher oxygen saturation in the first 30 hours.
Five subjects in the placebo group were intubated and ventilated after enrolment compared with none in the aminophylline group.
Conclusions-Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment.
Mots-clés Pascal : Etat mal asthmatique, Etude comparative, Etude double insu, Australie, Océanie, Aminophylline, Perfusion, Chimiothérapie, Efficacité traitement, Effet secondaire, Spirométrie, Saturation, Oxygène, Enfant, Homme, Adolescent, Adulte jeune, Xanthine dérivé, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Asthme, Antiasthmatique, Bronchodilatateur, Réanimation respiratoire, Unité soin intensif
Mots-clés Pascal anglais : Status asthmaticus, Comparative study, Double blind study, Australia, Oceania, Aminophylline, Perfusion, Chemotherapy, Treatment efficiency, Secondary effect, Spirometry, Saturation, Oxygen, Child, Human, Adolescent, Young adult, Xanthine derivatives, Respiratory disease, Obstructive pulmonary disease, Asthma, Antiasthma agent, Bronchodilator, Respiratory intensive care, Intensive care unit
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0535884
Code Inist : 002B11B. Création : 23/03/1999.