In a 6-year prospective study, the authors examined the relation between diet and incident colon cancer among 32,051 non-Hispanic white cohort members of the Adventist Health Study (California, 1976-1982) who, at baseline, had no documented or reported history of cancer.
The risk of colon cancer was determined from proportional hazards regression with adjustment for age and other covariates.
The authors found a positive association with total meat intake (risk ratio (RR) for >=1 time/week vs. no meat intake=1.85,95% confidence interval (Cl) 1.19-2.87 ; p for trend=0.01) and, among subjects who favored specific types of meat, positive associations with red meat intake (RR for >=1 time/week vs. no red meat intake=1.90,95% Cl 1.16-3.11 ; p for trend=0.02) and white meat intake (RR for >=1 time/week vs. no white meat intake=3.29,95% Cl 1.60-6.75 ; p for trend=0.006).
An inverse association with legume intake (RR for>2 times/week vs.<1 time/week=0.53,95% Cl 0.33-0.86 ; p for trend=0.03) was observed.
Among men, a positive association with body mass index was observed (relative to the RR for tertile III (>25.6 kg/m2) vs. tertile I (<22.5 kg/m2)=2.63,95% Cl 1.12-6.13 ; p for trend=0.05).
A complex relation was identified whereby subjects exhibiting a high red meat intake, a low legume intake, and a high body mass experienced a more than threefold elevation in risk relative to all other patterns based on these variables. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Régime alimentaire végétarien, Légume, Indice masse corporelle, Epidémiologie, Facteur risque, Homme, Californie, Etats Unis, Amérique du Nord, Amérique, Etude cohorte, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Alimentation
Mots-clés Pascal anglais : Malignant tumor, Colon, Vegetarian diet, Vegetable, Body mass index, Epidemiology, Risk factor, Human, California, United States, North America, America, Cohort study, Digestive diseases, Intestinal disease, Colonic disease, Feeding
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0533901
Code Inist : 002B13B01. Création : 23/03/1999.