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  1. Empirical criteria for the selection of quality-of-life instruments for the evaluation of peripheral blood progenitor cell transplantation.

    Article - En anglais

    We propose a method for selecting quality-of-life instruments for use in phase III trials using the convergent validity of patient responses collected in phase I and II clinical trials.

    Two generic and two disease-specific instruments were administered to patients with breast cancer undergoing peripheral blood progenitor cell mobilization and transplantation.

    They included the visual analog scale from the EuroQoL EQ5D instrument, the SF-36, the European Organization for Research and Treatment of Cancer (EORTC) - QLQ-C30, and the Functional Assessment of Cancer Therapy instrument.

    No single instrument was found to have superior convergent validity in all domains, but the EORTC-QLQ-C30 seemed to perform better than the SF-36.

    Mots-clés Pascal : Transplantation, Cellule souche, Cellule sanguine, Qualité vie, Indicateur, Traitement, Essai clinique, Tumeur maligne, Glande mammaire, Epidémiologie, Méthodologie, Homme, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie

    Mots-clés Pascal anglais : Transplantation, Stem cell, Blood cell, Quality of life, Indicator, Treatment, Clinical trial, Malignant tumor, Mammary gland, Epidemiology, Methodology, Human, United States, North America, America, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0533100

    Code Inist : 002B30A01A1. Création : 23/03/1999.