Because of previous inconsistencies in the observed relation of cigarette smoking to non-Hodgkin's lymphoma, this association was investigated in the Selected Cancers Study, a population-based case-control study of 1,193 non-Hodgkin's lymphoma cases and 1,903 controls, conducted between 1984 and 1988.
Study subjects were men, and the median age of non-Hodgkin's lymphoma cases was 50 years (range, 32-60 years).
As compared with the risk among men who had never smoked cigarettes, the risk among ever smokers was not increased (odds ratio (OR)=1.05, p ~ 0.50), but the risk was significantly elevated among men who reported smoking >=21/2 packs per day and among men who had smoked for 30-39 years (OR=1.45 in each group, p<0.05).
The estimated odds ratio among the 350 heavy smokers (>=50 pack-years) was 1.41 (95% confidence interval 1.08-1.85) after controlling for educational achievement, various occupational and medical exposures, and other potential confounders.
The observed associations, however, tended to vary by age, with the odds ratio among heavy smokers decreasing from 2.8 among 32-to 44-year-olds to 1.1 among men over 55 years of age.
These age-related differences, which may account for some of the inconsistencies seen in previous studies of cigarette smoking and non-Hodgkin's lymphoma, should be considered in future investigations.
Mots-clés Pascal : Tabagisme, Consommation, Durée, Cigarette, Lymphome non hodgkinien, Epidémiologie, Facteur risque, Adulte, Homme, Mâle, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Tobacco smoking, Consumption, Duration, Cigarette, Non Hodgkin lymphoma, Epidemiology, Risk factor, Adult, Human, Male, Case control study, United States, North America, America, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0532940
Code Inist : 002B19B. Création : 23/03/1999.