The authors describe a new simple noniterative, yet efficient method to estimate the risk ratio in studies using case-parental control design.
The new method is compared with two other noniterative methods, Khoury's method and Flanders and Khoury's method, and with a maximum likelihood-based method of Schaid and Sommer.
The authors found that the variance of the new estimation method is usually smaller than that of Khoury's method or Flanders and Khoury's method and that it is slightly larger than that of the maximum likelihood-based method of Schaid and Sommer.
Despite the slightly large variance of the new estimator compared with that of the maximum likelihood-based method, the simplicity of the new estimator and its variance makes the new method appealing.
When genotypic information for only one parent is available, the authors also describe a method to estimate the risk ratio without assuming Hardy-Weinberg equilibrium or random mating.
A simple formula for the variance of the estimator is given.
Mots-clés Pascal : Risque, Gène, Marqueur biologique, Marqueur génétique, Etude cas témoin, Méthodologie, Analyse statistique, Homme, Epidémiologie
Mots-clés Pascal anglais : Risk, Gene, Biological marker, Genetic marker, Case control study, Methodology, Statistical analysis, Human, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0532493
Code Inist : 002B30A01A1. Création : 23/03/1999.