The objective of this study was to examine how the major components of the insulin resistance syndrome relate to each other and to macrovascular disease in American Indians in the Strong Heart Study.
The study cohort (4,228 resident tribal members 45-74 years old) underwent a personal interview and a physical examination between July 1989 and January 1992 at three centers :
Oklahoma, and North and South Dakota ;
blood samples were drawn and a 75-g oral glucose tolerance test was performed.
Factor analysis was used to assess the clustering and interdependence of groups of insulin resistance syndrome variables.
Within both diabetic and nondiabetic groups, three factors emerged.
In nondiabetic participants, a cluster of glucose, body mass index, and insulin accounted for 35% (male) and 32% (female) of the total variance in all variables considered, and a cluster of systolic blood pressure and diastolic blood pressure accounted for 25% and 22% in men and women, respectively.
Both clusters were positively associated with coronary heart disease but not peripheral vascular disease.
In diabetic participants, the combination of systolic and diastolic blood pressures was the most important factor, but the cluster was not associated with coronary heart disease or peripheral vascular disease. (...)
Mots-clés Pascal : Diabète, Insuline, Résistance, Cardiopathie coronaire, Epidémiologie, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Etude comparative, Endocrinopathie
Mots-clés Pascal anglais : Diabetes mellitus, Insulin, Resistance, Coronary heart disease, Epidemiology, Risk factor, Human, United States, North America, America, Comparative study, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0532466
Code Inist : 002B12A03. Création : 23/03/1999.