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  1. Shared epitope'homozygosity'is strongly associated with rheumatoid arthritis in Turkey.

    Article - En anglais

    Objective

    Associations with HLA-DRB alleles, implicated in the aetiopathogenesis of rheumatoid arthritis (RA), are found to be different in various ethnic groups.

    This study aimed to investigate DRBI alleles in RA patients in Turkey.

    Methods

    The DRB region of the MHC was screened by polymerase chain reaction/sequence-specific oligonucleotide (PCR/SSO) hybridizations in 101 seropositive RA patients and compared with 101 healthy controls.

    Results

    Significant differences were in the frequencies of DRB1 *0404 (12 vs 1, P=0.003, OR=13.5), *0401 (19 vs 4. P=0.001, OR=5.6) and *0408 (5 vs 0, P=0.06, OR=11.6) between RA patients and controls.

    The shared epitope (SE) was present in 70.2% of RA patients compared to 31.6% of controls (P<0.0001, OR=5.1).

    A double dose of SE was considerably more frequent in the RA group (21 vs 1, P<0.0001, OR=26.5).

    Conclusion

    These results support the reported positive association of RA with SE in seropositive patients in Turkey, and emphasize'SE homozygosity'as the most strongly associated genetic susceptibility marker for RA.

    Mots-clés Pascal : Polyarthrite rhumatoïde, Pathogénie, Déterminisme génétique, Epidémiologie, Turquie, Asie, Ethnie, Réaction chaîne polymérase, Exploration, DNA, Système HLA-DR, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Biologie moléculaire

    Mots-clés Pascal anglais : Rheumatoid arthritis, Pathogenesis, Genetic determinism, Epidemiology, Turkey, Asia, Ethnic group, Polymerase chain reaction, Exploration, DNA, HLA-DR-System, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0531490

    Code Inist : 002B15D. Création : 23/03/1999.