Fibrinogen plasma levels in an apparently healthy general population : Relation to environmental and genetic determinants.
Elevated fibrinogen levels are an independent risk factor for cardiovascular ischemic disease.
We investigated the relationship between cardiovascular ischemic risk factors, the fibrinogen Bbêta-chain G/A-455 polymorphism and plasma fibrinogen levels in 989 apparently healthy subjects.
Fibrinogen values were higher in subjects with C reactive protein (C-RP)>0.33 mg/dl, BMI>23.9 kg/m2, total cholesterol>4.84 mmol/l, triglycerides>1.02 mmol/l, PAI-1 antigen>12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming>10 cigarettes per day (p<0.01).
Men and ethanol drinkers showed lower plasma fibrinogen levels (p<0.01).
The multivariate analysis confirmed the independent effect of C-RP, age, BMI, total cholesterol, gender, PAI-1, - 455 G/A polymorphism, (p<0.05).
BMI, total cholesterol, PAI-1, alcohol and smoking habit raised with the increase of age and differed between sexes.
The A-455 allele increasing effect was significant in women, especially in subjects aged<30 years, and in men aged<43 years.
These results indicate that environmental factors contributed to a larger extent to fibrinogen variability, whereas the A-455 allele was associated with a steeper increase in younger age quartiles.
Mots-clés Pascal : Fibrinogène, Facteur coagulation, Coagulation sanguine, Variabilité génétique, Sexe, Age, Lipide, Tabac, Alcool, Appareil circulatoire pathologie, Facteur risque, Epidémiologie, Etude cohorte, Italie, Europe, Etude statistique, Génétique
Mots-clés Pascal anglais : Fibrinogen, Coagulation factor, Blood coagulation, Genetic variability, Sex, Age, Lipids, Tobacco, Alcohol, Cardiovascular disease, Risk factor, Epidemiology, Cohort study, Italy, Europe, Statistical study, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0531077
Code Inist : 002A04I02. Création : 23/03/1999.