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  1. Sjögren's syndrome : A community-based study of prevalence and impact.

    Article - En anglais


    Using the European Community (EC) criteria for classification Vitali et al.

    Arthritis Rheum 1993 ; 36 : 340-7, we report the prevalence estimates of Sjögren's syndrome (SS) from a general population and present the first population data to assess the impact of the syndrome.


    A cross-sectional population-based survey performed on 1000 adults, aged 18-75 yr, randomly selected from a population register.

    Responders to the initial postal phase were invited for an interview.

    The five criteria measured at interview were :

    • (1) the reporting of subjective oral symptoms lasting for>3 months ;

    • (2) the reporting of subjective ocular symptoms lasting for>3 months ;

    • (3) Schirmer-I test ;

    • (4) unstimulated salivary flow ;

    • (5) autoantibodies [Ro (SS-A),

    • La (SS-B), rheumatoid factor (RF), antinuclear antibodies (ANA) ]. SS was diagnosed if at least four of these five criteria were positive.

    The MOS Short-form 36 (SF-36), General Health Questionnaire (GHQ) and the Health and Fatigue Questionnaire (HFQ) were completed by subjects after the interview, and scores were compared between those with and without a diagnosis of SS.


    A total of 341 subjects completed both the postal questionnaire and home visit.

    A diagnosis of SS could be given to 13 subjects.

    After adjusting for the presence of possible bias due to non-response, our best estimate of the prevalence of SS in the study population was 33 per 1000 subjects (95% CI 22-44). (...)

    Mots-clés Pascal : Sjogren syndrome, Adulte, Homme, Symptomatologie, Epidémiologie, Prévalence, Etude transversale, Vieillard, Coping, Psychométrie, Questionnaire, Oeil pathologie, Stomatologie, Maladie système, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Sjogren syndrome, Adult, Human, Symptomatology, Epidemiology, Prevalence, Cross sectional study, Elderly, Coping, Psychometrics, Questionnaire, Eye disease, Stomatology, Systemic disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0530935

    Code Inist : 002B07. Création : 23/03/1999.