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  1. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16.

    Article - En anglais

    Background & Aims 

    Inflammatory bowel disease (IBD) is a complex disorder of unknown etiology.

    Epidemiological investigations suggest a genetic basis for IBD.

    Recent genetic studies have identified several IBD linkages.

    The significance of these linkages will be determined by studies in large patient collections.

    The aim of this study was to replicate IBD linkages on chromosomes 12 and 16 in a large European cohort.

    Methods 

    Three hundred fifty-nine affected sibling pairs from 274 kindreds were genotyped using microsatellite markers spanning chromosomes 12 and 16.

    Affection status of the sibling pairs was defined as Crohn's disease (CD) or ulcerative colitis (UC).

    Results 

    Nonparametric statistical analyses showed linkage for both chromosomes.

    Two-point results for chromosome 12 peaked at D12S303 (logarithm of odds [LOD], 2.15 ; P=0.003) for CD and at D12S75 (LOD, 0.92 ; P=0.03) for UC.

    Multipoint analyses produced a peak LOD of 1.8 for CD.

    Chromosome 16 showed linkage for CD at marker D16S415 (LOD, 1.52 ; P=0.007).

    Multipoint support peaked above markers D16S409 and D16S411 (LOD, 1.7).

    Conclusions 

    These data are consistent with linkage of IBD to chromosomes 12 and 16.

    The replication of genetic risk loci in a large independent family collection indicates important and common susceptibility genes in these regions and will facilitate identification of genes involved in IBD.

    Mots-clés Pascal : Rectocolite ulcérohémorragique, Entérite Crohn, Colite, Prédisposition, Liaison génétique, Chromosome C12, Chromosome E16, Epidémiologie, Homme, Europe, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Génétique

    Mots-clés Pascal anglais : Ulcerative colitis, Crohn disease, Colitis, Predisposition, Linkage, Chromosome C12, Chromosome E16, Epidemiology, Human, Europe, Digestive diseases, Intestinal disease, Inflammatory disease, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0527177

    Code Inist : 002B13B03. Création : 23/03/1999.