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  1. Associations of fibrinogen, factor VII and PAI-1 with baseline findings among 10,500 male participants in a prospective study of myocardial infarction : The prime study.

    Article - En anglais

    The contribution of coagulation factors and fibrinolytic variables to the development of ischaemic arterial disease is still not clearly established.

    The PRIME study is a prospective cohort study of myocardial infarction in men aged 50-59 years and recruited from three MONICA field centers in France (Lille, Strasbourg and Toulouse) and the center in Northern Ireland (Belfast).

    Baseline examination included measurement of plasma fibrinogen, factor VII, and PAI-I activity in over 10.500 participants.

    We investigated the associations of these haemostatic variables with cardiovascular risk factors, prevalent atherosclerotic disease and geographical area.

    Fibrinogen level increased with age, smoking, waist-to-hip ratio, LDL-cholesterol, and it decreased with educational level, leisure physical activity, alcohol intake and HDL-cholesterol.

    Factor VII activity increased with body mass index, waist-to-hip ratio, triglycerides, HDL-and LDL-cholesterol.

    PAI-I activity increased with body mass index, waist-to-hip ratio, triglycerides, alcohol intake, smoking, and decreased with leisure physical activity.

    PAI-I level was higher in diabetic subjects than in subjects without diabetes.

    Cardiovascular risk factors explained 8%, 9%, and 26% of the total variance in fibrinogen, factor VII, and PAI-1, respectively. (...)

    Mots-clés Pascal : Athérosclérose, Infarctus, Myocarde, Facteur risque, Facteur coagulation, Facteur fibrinolyse, Fibrinogène, Inhibiteur plasminogen activator 1, Proconvertine, Etude cohorte, Variation géographique, Irlande, Europe, France, Epidémiologie, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie

    Mots-clés Pascal anglais : Atherosclerosis, Infarct, Myocardium, Risk factor, Coagulation factor, Fibrinolysis factor, Fibrinogen, Plasminogen activator inhibitor 1, Factor VII, Cohort study, Geographical variation, Ireland, Europe, France, Epidemiology, Human, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0523625

    Code Inist : 002B12A03. Création : 23/03/1999.