Automated cytology devices have utility in quality assurance applications, but the effectiveness of these devices in primary screening is unknown.
Enrollment smears obtained from 7323 women participating in a population-based study sponsored by the National Cancer Institute were screened manually in Costa Rica and then evaluated independently in the U.S. with the PAPNET system (Neuromedical Systems, Inc., Suffern, NY), a semiautomated, neural network-based device.
Smears with abnormal PAPNET images were microscopically rescreened and then diagnosed by a U.S. cytopathologist.
ThinPrep slides (Cytyc Corporation, Boxborough, MA), prepared from rinses of the cytologic sampler, and cervigrams (National Testing Laboratories, Fenton, MO) were also evaluated.
Women with any abnormal cytologic diagnosis or a positive cervigram were referred for colposcopy with biopsy and definitive therapy if indicated.
Based on the U.S. cytotechnologist's review of the PAPNET images, 1017 (13.9%) of 7323 smears were selected for manual screening, resulting in the selection of 492 (6.7%) possibly abnormal slides for referral to the U.S. pathologist.
Ultimately, 312 smears (4.3% of the total) were diagnosed as containing squamous cells of undetermined significance or a more severe abnormality (>=ASCUS), resulting, hypothetically, in the referral of 66.5% of women with a final diagnosis of a squamous intraepithelial lesion or a more severe abnormality (>=SIL) and 86. (...)
Mots-clés Pascal : Carcinome, Col utérus, Frottis cervical, Dépistage, Test Papanicolaou, Cytologie, Semiautomatique, Evaluation performance, Costa Rica, Amérique Centrale, Amérique, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne, Anatomopathologie
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Cervical smear, Medical screening, Papanicolaou smear test, Cytology, Semiautomatic, Performance evaluation, Costa Rica, Central America, America, Human, Female genital diseases, Uterine cervix diseases, Malignant tumor, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0519619
Code Inist : 002B24O11. Création : 23/03/1999.