This study examines the relationship between a series of epidemiologic parameters (age, height, body mass index (BMI), smoking, alcohol consumption, and coffee drinking) and serum concentrations of testosterone, estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS).
Among 52 healthy, elderly Greek men, we observed that serum levels of DHEAS decreased with increasing age [19% decline per 5-year increase in age, 95% CI, - 2.1--33.5], obesity [48% decline for BMI>30 kg/m2 compared to<27 kg/m2, Cl, - 15.7--68.7], and current smoking [37% decline compared to nonsmokers, Cl, - 9.5--57.2]. Estradiol concentrations increased with increasing BMI [77.1% increase for BMI>30 kg/m2 compared to<27 kg/m2, Cl, - 12.0-256.3], alcohol drinking [66% increase for >=7 glasses/week compared to<7 glasses/week, Cl, 4.4-164.4], and coffee drinking [59% increase for >=14 cups/week compared to >=14 cups/week, Cl, - 0.5-155.9], and decreased among current smokers [40% decline compared to nonsmokers, CI, - 64.9-0.8]. SHBG was marginally positively associated with increasing age [13% increase per 5 years, CI, - 0.5-29.6]. Testosterone was significantly related only to current smoking [27% decline compared to nonsmokers, CI, - 45.4--3.1]. These findings suggest that several variables appear to be associated with sex steroid levels and the influence of these findings on the occurrence of hormone-related conditions warrants further exploration.
Mots-clés Pascal : Testostérone, Estradiol, Protéine liaison hormone stéroïde sexuelle, Déhydroépiandrostérone sulfate, Prédicteur, Age, Mode de vie, Poids corporel, Epidémiologie, Taux, Plasma sanguin, Vieillard, Homme, Mâle, Grèce, Europe, Hormone stéroïde sexuelle
Mots-clés Pascal anglais : Testosterone, Estradiol, Sex hormone binding protein, Dehydroepiandrosterone sulfate, Predictor, Age, Life habit, Body weight, Epidemiology, Rate, Blood plasma, Elderly, Human, Male, Greece, Europe, Sex steroid hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0512452
Code Inist : 002A28G. Création : 23/03/1999.