Objectives-To investigate the early migration patterns of children who later developed cancer.
To test a prior hypothesis that some cancers are initiated by early exposures to toxic atmospheric pollutants from point sources.
Design-Address changes in children dying from cancer are examined in relation to potentially hazardous sites of several different types.
The relative proximities of birth addresses and death addresses to these sites, are compared.
The approach is based upon the premise that a local exposure, effective only at an early age, must be preferentially linked with an early address.
Setting and Subjects-Records of 22 458 children dying from leukaemia or other cancer under the age of 16 years in Great Britain between 1953 and 1980 : including 9224 who moved house between birth and death.
The migration analysis was based upon birth and death addresses, converted first to postcodes and thence to map coordinates.
The geographical locations of potentially toxic industrial sites were obtained through direct map searches and from commercial directories.
Systematic asymmetries were found between measured distances from birth and death addresses to sources emitting volatile organic compounds, or using large scale combustion processes.
The children had more often moved away from these hazards than towards them.
Many of the sources had already been identified as hazardous using other methods. (...)
Mots-clés Pascal : Tumeur maligne, Pollution air, Exposition, Polluant, Toxicité, Variation géographique, Migration, Epidémiologie, Facteur risque, Enfant, Homme, Grande Bretagne, Royaume Uni, Europe
Mots-clés Pascal anglais : Malignant tumor, Air pollution, Exposure, Pollutant, Toxicity, Geographical variation, Migration, Epidemiology, Risk factor, Child, Human, Great Britain, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0512209
Code Inist : 002B04B. Création : 23/03/1999.