Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus : Prevalence, clinical associations and correlation with other autoantibodies.
Objectives To evaluate, in a cohort of 566 patients with systemic lupus erythematosus (SLE) drawn from 11 European centres :
(i) the prevalence of ANCAs and their subspecificities in a large series of European SLE patients ;
(ii) the possible associations of ANCA with the most common clinical manifestations of the disease ;
and (iii) whether ANCAs correlate with some of the autoantibodies commonly found in SLE.
Methods ANCA detection was perfomed by indirect immunofluorescence (IIF), and by ELISA for lactoferrin (LF), myeloperoxydase (MPO), proteinase3 (PR3) and lysozyme (LZ) subspecificities.
Results The prevalence of ANCA was 16.4% (IIF).
The prevalence ofLF was 14.3%, LZ 4.6%, MPO 9.3%, and PR3 1.7%. Our results show thatANCA is associated with certain clinical manifestations of SLE.
In particular, positive correlations were found between IIFANCA and serositis (p=0.026), livedo reticularis (p=0.01), venous thrombosis (p=0.03) and arthritis (p=0.04), while anti-LF antibodies were associated with serositis (p=0.05) and livedo reticularis (p<10-3).
Nevertheless, multivariate analysis demonstrated that other autoantibodies, such as aCL and SSA/Ro, are more closely correlated than ANCA with some of the aforementioned clinical features.
Conclusion Our results demonstrate that ANCA are detectable in SLE sera and that some of them are associated with particular clinical manifestations. (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Homme, Epidémiologie, Prévalence, Symptomatologie, Analyse corrélation, Anticorps, Autoanticorps, Anticorps anticytoplasme polynucléaire neutrophile, Technique ELISA, Immunofluorescence indirecte, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Human, Epidemiology, Prevalence, Symptomatology, Correlation analysis, Antibody, Autoantibody, Antineutrophil cytoplasmic antibody, ELISA assay, Indirect immunofluorescence, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0511810
Code Inist : 002B07. Création : 23/03/1999.