Early clinical markers for the development of bronchopulmonary dysplasia : Soluble E-Selectin and ICAM-1.
To test the hypothesis that in infants born at <=29 weeks'gestation soluble adhesion molecule concentrations would be higher in the first week of life in infants that subsequently develop bronchopulmonary dysplasia than in infants that do not.
Design and Methods
In cord blood and on days of life 1,3, and 7, we measured serum concentrations of soluble P-Selectin, E-Selectin, and intercellular adhesion molecule-1 in samples obtained from infants <=29 weeks'gestational age.
At 1 month of age we assessed the infants'clinical courses to determine whether the infants met the criteria for the diagnosis of bronchopulmonary dysplasia (BPD) and evaluated the infants'radiographic studies to stage the level of BPD.
On discharge, the duration of oxygen therapy, the requirement for home oxygen therapy, and length of hospital stay were determined.
Concentrations of soluble P-Selectin were greatest in cord blood samples obtained from all infants and were markedly reduced on day of life 1, regardless of the subsequent development of BPD.
In serum samples obtained from cord blood and on days of life 1 and 3, soluble E-Selectin levels were higher in infants that developed BPD than in infants that did not develop BPD.
In addition, the highest concentrations of soluble E-Selectin in serum samples from cord blood and on day of life 1 were associated with the development of stage 3 or 4 BPD. (...)
Mots-clés Pascal : Dysplasie bronchopulmonaire, Soin intensif, Détresse respiratoire, Poids naissance extrêmement faible, Biologie clinique, Inflammation, Protéine ICAM1, Sélectine E, Sélectine P, Etude statistique, Marqueur biologique, Prématuré, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Nouveau né pathologie, Gestation pathologie
Mots-clés Pascal anglais : Bronchopulmonary dysplasia, Intensive care, Respiratory distress, Extremely low birthweight, Clinical biology, Inflammation, Intercellular adhesion molecule 1, E Selectin, P Selectin, Statistical study, Biological marker, Premature, Respiratory disease, Lung disease, Bronchus disease, Newborn diseases, Pregnancy disorders
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0511764
Code Inist : 002B27B11. Création : 23/03/1999.