logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Autoantibodies in Estonia and sweden, populations with different responses to allergens.

    Article - En anglais

    Background 

    There are substantial differences in immune-mediated disease prevalence between different countries and populations which cannot be explained by genetic variability.

    Aims 

    To compare the prevalence of antinuclear (ANA), antimitochondrial, antireticulin, liver-kidney microsomal, parietal cell, thyroid microsomal and double-stranded DNA (dsDNA) antibodies among adults aged 20-44 years in two towns, i.e. in Tartu, Estonia (n=448) and in Uppsala, Sweden (n=532) with a low and a high prevalence of allergy.

    Methods 

    For autoantibody detection, standard indirect immunofluorescence tests on tissue and Chritidia lucilia antigenic preparations were used (sera were diluted starting from 1 : 10).

    Results 

    The prevalence of ANA was lower in Tartu than in Uppsala (3 vs. 10% among males and 1 1 vs. 16% among females ; p<0.01 and p<0.1, respectively).

    Furthermore, dsDNA antibody-positive cases were only identified in Uppsala.

    The largest difference between the two populations was revealed for IgM type ANA, both among males (1 vs. 6% ; p<0.02) and females (5 vs. 11% : p<0.01).

    In addition, the antibody titers were lower in Tartu than in Uppsala (p<0.05).

    The prevalence of other autoantibodies was similar in the two towns.

    Conclusions 

    The findings could support that Th2-like immune responses are commoner in Sweden than in Estonia, as previously suggested by the higher prevalence of allergy.

    Mots-clés Pascal : Allergie, Prévalence, Sérologie, Anticorps, Autoanticorps, Exploration immunologique, Estonie, Europe Est, Europe, Suède, Réponse immune, Lymphocyte T, Sous population cellulaire, Cellule helper, Immunité cellulaire, Epidémiologie, Etude comparative, Homme, Immunopathologie, Lymphocyte Th2

    Mots-clés Pascal anglais : Allergy, Prevalence, Serology, Antibody, Autoantibody, Immunological investigation, Estonia, Eastern Europe, Europe, Sweden, Immune response, T-Lymphocyte, Cell subpopulation, Helper cell, Cellular immunity, Epidemiology, Comparative study, Human, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0509146

    Code Inist : 002B06C01. Création : 23/03/1999.