Autoantibodies in Estonia and sweden, populations with different responses to allergens.
There are substantial differences in immune-mediated disease prevalence between different countries and populations which cannot be explained by genetic variability.
To compare the prevalence of antinuclear (ANA), antimitochondrial, antireticulin, liver-kidney microsomal, parietal cell, thyroid microsomal and double-stranded DNA (dsDNA) antibodies among adults aged 20-44 years in two towns, i.e. in Tartu, Estonia (n=448) and in Uppsala, Sweden (n=532) with a low and a high prevalence of allergy.
For autoantibody detection, standard indirect immunofluorescence tests on tissue and Chritidia lucilia antigenic preparations were used (sera were diluted starting from 1 : 10).
The prevalence of ANA was lower in Tartu than in Uppsala (3 vs. 10% among males and 1 1 vs. 16% among females ; p<0.01 and p<0.1, respectively).
Furthermore, dsDNA antibody-positive cases were only identified in Uppsala.
The largest difference between the two populations was revealed for IgM type ANA, both among males (1 vs. 6% ; p<0.02) and females (5 vs. 11% : p<0.01).
In addition, the antibody titers were lower in Tartu than in Uppsala (p<0.05).
The prevalence of other autoantibodies was similar in the two towns.
The findings could support that Th2-like immune responses are commoner in Sweden than in Estonia, as previously suggested by the higher prevalence of allergy.
Mots-clés Pascal : Allergie, Prévalence, Sérologie, Anticorps, Autoanticorps, Exploration immunologique, Estonie, Europe Est, Europe, Suède, Réponse immune, Lymphocyte T, Sous population cellulaire, Cellule helper, Immunité cellulaire, Epidémiologie, Etude comparative, Homme, Immunopathologie, Lymphocyte Th2
Mots-clés Pascal anglais : Allergy, Prevalence, Serology, Antibody, Autoantibody, Immunological investigation, Estonia, Eastern Europe, Europe, Sweden, Immune response, T-Lymphocyte, Cell subpopulation, Helper cell, Cellular immunity, Epidemiology, Comparative study, Human, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0509146
Code Inist : 002B06C01. Création : 23/03/1999.