Objectives-To examine the relation between exposure to acid anhydrides and the risk of developing immediate skin prick test responses to acid anhydride human serum albumin (AA-HSA) conjugates or work related respiratory symptoms ; to assess whether these relations are modified by atopy or smoking.
Methods-A cohort of 506 workers exposed to phthalic (PA), maleic (MA), and trimellitic anhydride (TMA) was defined.
Workers completed questionnaires relating to employment history, respiratory symptoms, and smoking habits.
Skin prick tests were done with AA-HSA conjugates and common inhalant allergens.
Exposure to acid anhydrides was measured at the time of the survey and a retrospective exposure assessment was done.
Information was obtained from 401 (79%) workers.
Thirty four (8.8%) had new work related respiratory symptoms that occurred for the first time while working with acid anhydrides and 12 (3.2%) were sensitised, with an immediate skin prick test reaction to AA-HSA conjugates.
Sensitisation to acid anhydrides was associated with work related respiratory symptoms and with smoking at the time of exposure to acid anhydride. (...)
Mots-clés Pascal : Anhydride organique, Acide organique, Toxicité, Industrie chimique, Exposition professionnelle, Etude cohorte, Homme, Facteur risque, Sensibilisation, Appareil respiratoire pathologie, Médecine travail, Relation dose réponse, Comparaison interindividuelle, Tabagisme, Atopie
Mots-clés Pascal anglais : Organic anhydride, Organic acids, Toxicity, Chemical industry, Occupational exposure, Cohort study, Human, Risk factor, Sensitization, Respiratory disease, Occupational medicine, Dose activity relation, Interindividual comparison, Tobacco smoking, Atopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0505365
Code Inist : 002B03L06. Création : 19/02/1999.