Dementia and occupational exposure to organic solvents.
Objectives-To investigate whether occupational exposure to organic solvents increases the risk of dementia Methods-Cases of dementia were identified from the computed tomography records of eight neuroradiology centres in England and Wales, and were compared with two sets of controls investigated at the same centres.
The first set of controls were patients with brain cancer and the second set were patients with other disorders that were not chronically disabling.
Lifetime occupational histories were obtained through a postal questionnaire completed by the subjects or their next of kin.
Associations between dementia and occupation were examined by logistic regression.
Usable questionnaires were returned for 204 (61%) ofthe cases, 225 (51%) of the controls with brain cancer, and 441 (61%) of the other controls.
The findings with each of the two sets of controls were similar.
In comparison with all controls combined, cases had less often worked ever as a painter or printer (odds ratio (OR) 0.6,95% confidence interval (95% CI) 0.3 to 1.2), and were less likely to have worked for>1 year as a printer, painter, or launderer or dry cleaner (OR 0.6,95% CI 0.3 to 1.4).
Conclusions-These findings provide no support for the hypothesis that occupational exposure to solvents is a cause of dementia. (...)
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Démence, Système nerveux central pathologie, Etude cohorte, Homme, Evaluation, Facteur risque, Encéphale, Médecine travail, Toxicité, Inhalation, Etude statistique, Prévalence, Trouble psychiatrique, Système nerveux pathologie
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Dementia, Central nervous system disease, Cohort study, Human, Evaluation, Risk factor, Brain (vertebrata), Occupational medicine, Toxicity, Inhalation, Statistical study, Prevalence, Mental disorder, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0503767
Code Inist : 002B03L04. Création : 19/02/1999.