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  1. Retrospective exposure assessment for a cohort study into respiratory effects of acid anhydrides.

    Article - En anglais

    Objectives-To estimate past exposure to phthalic (PA), trimellitic (TMA) and maleic anhydride (MA) in three alkyd resin and one cushioned flooring factory to estimate exposure-response relations in a retrospective cohort study.

    Methods-Personal exposure measurements were carried out in 1992 and quantitative and qualitative information on past exposure and production processes were collected.

    Job titles were ranked by decreasing exposure and amalgamated into job categories and exposure groups.

    Multiplication factors for back calculating past exposure levels were estimated with past exposure data, or if no such data were available these factors were estimated by a panel of occupational hygienists.

    Exposure levels were back calculated starting with the exposure levels in 1992.


    High exposures to PA were estimated to have occurred among workers operating the PA melting pots in factory 1 (estimated exposure in 1960-9 was 2480 mug. m-3).

    Highest concentrations of TMA were estimated to have occurred among the ink mixers in factory 2 from 1979 to 1986 (554 mug. m-3).

    Exposure in most other job titles was thought to be fairly constant over time for PA, TMA, and MA.

    Conclusions-Exposure to acid anhydride at these factories has fallen during the period covered by the study.

    However, it is estimated that in only one job in factory 2 did past exposure to acid anhydride exceed the current occupational exposure standard. (...)

    Mots-clés Pascal : Anhydride organique, Acide organique, Toxicité, Industrie chimique, Antécédent, Etude cohorte, Exposition professionnelle, Teneur air ambiant, Lieu travail, Facteur risque, Poste travail, Estimation a posteriori, Homme, Médecine travail, Appareil respiratoire pathologie, Phtalique acide, Furane-2,5-dione(2,5-dihydro), Histoire professionnelle, Trimellitique acide, Benzène-1,2,4-tricarboxylique acide

    Mots-clés Pascal anglais : Organic anhydride, Organic acids, Toxicity, Chemical industry, Antecedent, Cohort study, Occupational exposure, Ambient air concentration, Work place, Risk factor, Workplace layout, A posteriori estimation, Human, Occupational medicine, Respiratory disease, Phthalic acid, 2,5-Furandione(2,5-dihydro)

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0503763

    Code Inist : 002B03L06. Création : 19/02/1999.