Transforming growth factor-bêta (TGF-bêta) is both abundant in bone and an important regulator of bone metabolism.
A T-C transition at nucleotide 29 in the signal sequence region of the TGF-bêta1 gene results in a Leu-Pro substitution at amino acid position 10.
The possible association of this polymorphism with bone mass and the prevalence of osteoporosis has now been investigated in a total of 287 postmenopausal women from two regions (Obu City, Aichi Prefecture, and Sanda City, Hyogo Prefecture) of Japan.
A significant association of TGF-bêta1 genotype with bone mass was detected in both populations ; bone mineral density (BMD) at the lumbar spine was greater in individuals with the CC genotype than in those with the TT or TC genotype.
The frequency of vertebral fractures was significantly lower in individuals with the CC genotype than in those with the TC or TT genotypes.
For each region, multivariable logistic regression analysis revealed that the frequency of the T allele was significantly higher in subjects with osteoporosis than in controls.
Also, the serum concentration of TGF-bêta1 in individuals with the CC genotype was significantly higher than that in age-matched subjects with the TC or TT genotype in osteoporotic or osteopenic as well as healthy control groups. (...)
Mots-clés Pascal : Postménopause, Polymorphisme, Gène, Facteur croissance transformant bêta1, Déterminisme génétique, Masse osseuse, Ostéoporose, Facteur risque, Japon, Asie, Epidémiologie, Système ostéoarticulaire, Système ostéoarticulaire pathologie, Ostéopathie, Homme, Femelle
Mots-clés Pascal anglais : Postmenopause, Polymorphism, Gene, Transforming growth factor bêta1, Genetic determinism, Bone mass, Osteoporosis, Risk factor, Japan, Asia, Epidemiology, Osteoarticular system, Diseases of the osteoarticular system, Bone disease, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0502683
Code Inist : 002B15A. Création : 19/02/1999.