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  1. Immune mechanisms of the occupational sensitization with methylen-dyphenyl diisocyanate (MDI).

    Article - En anglais

    The aim of this study was to obectify and to clarity some mechanisms of the immune response of the professional sensitization with MDI. 26 workers were tested for sensitization of immediate type (ST with a broad set of indoor allergens and serum MDI-IgE) and of delayed type (ST with a standard battery of antigens for cellulmar immunity and with MDI), also the lymphocyte sub-populations and their functional state by flow cytometric analysis.

    The most frequent allergic complaints were : rhinitis (70%), skin manifestations (53%), conjunctivitis (35%) and initial bronchial asthma in two cases (12%). We found indoor sensitization in 41% and normal cellular immune reactivity in all the workers tested.

    Specific MDI sensitization of immediate type was found in 28.5% of the workers and of delayed type - in 70% of the workers with allergic complaints.

    The laboratory immune indices suggest prevalence of cell-mediated mechanisms for the workers with allergic symptoms - production of INFgamma, responding to stimulation and deficient or insignificant production of IL-4, as well as linear correlation between the data for CMI, INFgamma and IL-4.

    Our results suggest the participation of more than one mechanism of immune injury in the clinically manifested allergic reactions.

    Mots-clés Pascal : Médecine travail, Bulgarie, Europe, Homme, Cytométrie flux, Réponse immune, Immunité cellulaire, Allergie, Uréthanne polymère, Exposition professionnelle, Immunopathologie, Méhylène-diphényl diisocyanate

    Mots-clés Pascal anglais : Occupational medicine, Bulgaria, Europe, Human, Flow cytometry, Immune response, Cellular immunity, Allergy, Polyurethane, Occupational exposure, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0500770

    Code Inist : 002B03L06. Création : 19/02/1999.