To assess both the prevalence and the characteristics of motor disorders of the small bowel in patients with systemic sclerosis (SSc) and to investigate for an association between clinical manifestations in the upper intestinal tract, capillaroscopic features, esophageal motor impairment, and manometric evidence of motor disturbances.
Fasting and postprandial motor activity of the upper intestinal tract was studied in 17 consecutive patients with SSc (6 with and 11 without clinical manifestations of small bowel involvement) and 17 age-and sex-matched healthy control subjects.
The prevalence of manometric evidence of intestinal involvement was as high as 88% in the SSc patients ; normal motor activity was present in only 2 patients.
The median values for duodenal and jejunal interdigestive phase III migrating motor complex duration, amplitude, and velocity and the postprandial motility index were therefore lower in SSc patients compared with controls.
Our manometric findings indicated that there are both neuropathic and myopathic stages of upper intestinal tract dysfunction in SSc.
Furthermore, no association could be found between the severity of the intestinal manometric abnormalities and clinical presentation, SSc subsets, disease score, capillaroscopic findings, or esophageal manometric impairment. (...)
Mots-clés Pascal : Sclérodermie, Exploration, Voie aérodigestive supérieure, Manométrie, Motricité, Symptomatologie, Epidémiologie, Prévalence, Homme, Pseudoocclusion, Intestin, Etude longitudinale, Malabsorption intestinale, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Appareil digestif pathologie, Intestin pathologie
Mots-clés Pascal anglais : Scleroderma, Exploration, Upper aerodigestive tract, Manometry, Motricity, Symptomatology, Epidemiology, Prevalence, Human, Pseudoobstruction, Gut, Follow up study, Intestinal malabsorption, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Digestive diseases, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0499576
Code Inist : 002B07. Création : 19/02/1999.