Polymorphisms of platelet membrane glycoprotein Ibalpha associated with arterial thrombotic disease.
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi.
Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIbalpha.
The relevance of these polymorphisms to thrombotic disease was investigated by genotypic identification in three case-control studies : 104 case patients with acute cerebrovascular disease (CVD), 101 case patients with acute coronary heart disease (CHD), 95 patients with deep venous thrombosis (DVT), and one control age-sex-and race-matched for each case patient.
Results show that the C/B genotype of the VNTR and the HPA-2b polymorphisms of GPIbalpha are strongly associated with increased risk of coronary heart disease and cerebral vascular disease but not with deep vein thrombosis.
These two polymorphisms of GPIbalpha may represent newly identified risk factors for arterial thrombotic disease, but not for venous thrombosis.
Mots-clés Pascal : Thrombose, Artère, Glycoprotéine, Protéine membranaire, Thrombocyte, Variabilité génétique, Facteur risque, Génotype, Epidémiologie, Etude cas témoin, Espagne, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie, Génétique, Glycoprotéine Ibalpha
Mots-clés Pascal anglais : Thrombosis, Artery, Glycoproteins, Membrane protein, Platelet, Genetic variability, Risk factor, Genotype, Epidemiology, Case control study, Spain, Europe, Human, Cardiovascular disease, Vascular disease, Arterial disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0499399
Code Inist : 002B12B03. Création : 19/02/1999.