Long-term effect of Helicobacter pylori eradication on gastric metaplasia in patients with duodenal ulcer.
There have been conflicting reports on the effect of Helicobactor pylori eradication on gastric metaplasia in the duodenal bulb (DGM).
In the present study, we have investigated the relationships between DGM and H. pylori by examining whether or not H. pylori-positive patients had more DGM than H. pylori-negative patients with nonulcer dyspepsia (NUD) or duodenal ulcer (DU), and by examining the effect of eradication of H. pylori on the prevalence and the extent of DGM during the long-term up to 4 years.
Fifty H. pylori-positive and seven H. pylori-negative patients with DU and 23 H. pylori-positive and 23 H. pylori-negative NUD subjects were studied.
Two duodenal bulb biopsy specimens were taken for histologic evaluation and the presence and the extent of DGM were evaluated.
The extent of DGM was classified as none (grade 0), focal (grade I), multifocal (grade 2), and diffuse type (grade 4).
In H. pylori-positive patients with DU, follow-up gastroscopy was conducted 4 weeks, I year, and 4 years after H. pylori eradication.
DGM was significantly (p<0.001) more common (DU : 93%, NUD : 22%) and significantly (p<0.001) greater in extent for patients with DU than for NUD sub jects (DU : 1.89, NUD : 0.28).
Neither the prevalence nor the extent of DGM was affected by H. pylori status in patients with DU or NUD : the prevalence (extent) of DGM of H. pylori-positive and - negative patients with DU were 96% (1.94) and 71% (1.57), respectively.
In the 43 H. (...)
Mots-clés Pascal : Ulcère, Duodénum, Etiologie, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Facteur risque, Complication, Métaplasie, Estomac, Etude longitudinale, Eradication, Long terme, Homme, Corée, Asie, Appareil digestif pathologie, Intestin pathologie, Bactériose, Infection, Tumeur maligne, Estomac pathologie
Mots-clés Pascal anglais : Ulcer, Duodenum, Etiology, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Risk factor, Complication, Metaplasia, Stomach, Follow up study, Eradication, Long term, Human, Korea, Asia, Digestive diseases, Intestinal disease, Bacteriosis, Infection, Malignant tumor, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0499361
Code Inist : 002B05B02F. Création : 19/02/1999.