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  1. Clinical impact of screening first-degree relatives of patients with hepatocellular carcinoma.

    Article - En anglais

    Family history is a risk factor for hepatocellular carcinoma (HCC).

    However, the risk of first-degree relatives is not known.

    To investigate the risk of HCC among the first-degree relatives of probands and whether screening can lead to early diagnosis of HCCs in these relatives, we conducted a screening program.

    The probands'first-degree relatives who were>20 years old were included.

    Serum aminotransferase, hepatitis viral marker, alpha-fetoprotein, and abdominal sonography were done.

    HCCs were found in 20 (1.9%) of the 1,046 first-degree relatives, especially in the male siblings.

    Eighty-five percent of these 20 HCC patients were hepatitis B virus carriers.

    Forty percent of these 20 HCC patients had tumors<5 cm.

    Approximately 55% of these 20 HCCs were resectable.

    The 1-year survival rate in these 20 HCC patients with resectable HCCs was 72.7%, However, the overall 1-year survival rate was only 40%. We found HCC in 1.9% of the first-degree relatives of HCC patients.

    The male relatives, especially the older brothers, were the group at highest risk.

    The familial HCCs were closely related to the hepatitis B virus infection.

    To detect HCCs early, initial screening should be done as early as possible on the HCC family members.

    Mots-clés Pascal : Carcinome hépatocellulaire, Dépistage, Milieu familial, Histoire familiale, Facteur risque, Diagnostic, Imagerie ultrasonore, Marqueur tumoral, Homme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Radiodiagnostic, Imagerie médicale

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Medical screening, Family environment, Family story, Risk factor, Diagnosis, Ultrasound imaging, Tumoral marker, Human, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor, Radiodiagnosis, Medical imagery

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0499161

    Code Inist : 002B13C01. Création : 19/02/1999.