Family history is a risk factor for hepatocellular carcinoma (HCC).
However, the risk of first-degree relatives is not known.
To investigate the risk of HCC among the first-degree relatives of probands and whether screening can lead to early diagnosis of HCCs in these relatives, we conducted a screening program.
The probands'first-degree relatives who were>20 years old were included.
Serum aminotransferase, hepatitis viral marker, alpha-fetoprotein, and abdominal sonography were done.
HCCs were found in 20 (1.9%) of the 1,046 first-degree relatives, especially in the male siblings.
Eighty-five percent of these 20 HCC patients were hepatitis B virus carriers.
Forty percent of these 20 HCC patients had tumors<5 cm.
Approximately 55% of these 20 HCCs were resectable.
The 1-year survival rate in these 20 HCC patients with resectable HCCs was 72.7%, However, the overall 1-year survival rate was only 40%. We found HCC in 1.9% of the first-degree relatives of HCC patients.
The male relatives, especially the older brothers, were the group at highest risk.
The familial HCCs were closely related to the hepatitis B virus infection.
To detect HCCs early, initial screening should be done as early as possible on the HCC family members.
Mots-clés Pascal : Carcinome hépatocellulaire, Dépistage, Milieu familial, Histoire familiale, Facteur risque, Diagnostic, Imagerie ultrasonore, Marqueur tumoral, Homme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Radiodiagnostic, Imagerie médicale
Mots-clés Pascal anglais : Hepatocellular carcinoma, Medical screening, Family environment, Family story, Risk factor, Diagnosis, Ultrasound imaging, Tumoral marker, Human, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor, Radiodiagnosis, Medical imagery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0499161
Code Inist : 002B13C01. Création : 19/02/1999.