The relation between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is not clearly defined.
Some investigators suggest that patients with extensive colitis have a genetic predisposition to CRC and that long-standing inflammation is not of primary importance in the promotion of cancer.
We have assessed any increased risk of colon cancer in the relatives of IBD patients.
We studied the prevalence of malignancy in the relatives of 251 IBD patients [198 ulcerative colitis (UC) ; 53 Crohn's disease of the colon (CDC) ] and 251 orthopedic patients (ORTHO) as controls.
In all patients (UC, CDC) as well as in controls (ORTHO) the prevalence of colon, extracolic digestive and extradigestive malignant tumors in the first-degree relatives was evaluated.
We found no significant difference in the number of colorectal tumors or of tumors of any other kind in the diverse group of relatives of patients with IBD and ORTHO patients.
Our data do not point to the existence of hereditary factors linking UC or CDC to CRC.
Mots-clés Pascal : Rectocolite ulcérohémorragique, Entérite Crohn, Prévalence, Malignité, Facteur risque, Etude cas témoin, Carcinome, Côlon, Rectum, Etude comparative, Homme, Italie, Europe, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Tumeur maligne, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Ulcerative colitis, Crohn disease, Prevalence, Malignancy, Risk factor, Case control study, Carcinoma, Colon, Rectum, Comparative study, Human, Italy, Europe, Digestive diseases, Intestinal disease, Inflammatory disease, Malignant tumor, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0499151
Code Inist : 002B13B03. Création : 19/02/1999.