Glutathione S-transferase M1 and P1 genotypes and urinary excretion of 1-hydroxypyrene in coke oven workers.
The objective of this study was to analyze the effect of the GSTMI and GSTPI genotypes on urinary 1-hydroxypyrene, a biomarker for exposure to polycyclic aromatic hydrocarbon.
Urine samples were collected from coke oven workers at two time points (from 66 and 46 workers, respectively) and 1-hydroxypyrene was quantitated by HPLC chromatography.
The genotype of GSTMI and GSTPI was determined by a PCR methods discriminating between GSTMI present or absent and three different alleles for GSTPI.
The mean value of urinary 1-hydroxypyrene was higher at both time points in coke oven workers with GSTMI gene present compared to workers having the GSTMI null genotype, but this difference was not statistically significant.
The GSTMI and GSTPI genotypes were not significant parameters in a multiple regression analysis with urinary 1-hydroxypyrene as the dependent variable and with GSTM1, GSTP1, exposure group and smoking habit as explanatory variables.
The biomarker 1-hydroxypyrene is not or only marginally influenced by the GSTMI genotype.
No systematic influence of the GSTPI genotypes was found.
Mots-clés Pascal : Composé aromatique polycyclique, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Urine, Marqueur biologique, Comparaison interindividuelle, Génotype, Glutathione transferase, Transferases, Enzyme, Four coke, Pyrène(1-hydroxy)
Mots-clés Pascal anglais : Polycyclic aromatic compound, Occupational exposure, Occupational medicine, Human, Biological monitoring, Urine, Biological marker, Interindividual comparison, Genotype, Glutathione transferase, Transferases, Enzyme, Coke oven
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0498294
Code Inist : 002B03L06. Création : 19/02/1999.