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  1. A cost analysis of long term antibiotic prophylaxis for spontaneous bacterial peritonitis in cirrhosis.

    Article - En anglais


    The aim of this study was to perform a cost analysis of different strategies of long term antibiotic prophylaxis for spontaneous bacterial peritonitis (SBP) in patients with cirrhosis and ascites.

    The study involved a cost analysis using a decision analysis model and patients with cirrhosis and ascites who are at risk for developing SBP.


    Two different strategies of antibiotic prophylaxis were compared with a « no prophylaxis » strategy in patients with cirrhosis and ascites using a decision analysis model.

    In strategy I, antibiotic prophylaxis was administered in all patients with cirrhosis and ascites and in strategy II, patients were stratified into a low risk and a high risk group on the basis of serum bilirubin and ascitic fluid protein levels ; only patients in the high risk group received antibiotic prophylaxis.

    The cost per patient treated for 1 yr was the outcome measure compared in the different strategies.

    Clinical input probabilities and ranges used were obtained by searching the MEDLINE database for English language articles.

    Cost estimates were obtained from a university hospital setting.

    Cost analysis was done with a societal perspective, and only direct costs were taken into account.

    Sensitivity analyses were performed to evaluate the effect of variations in the key clinical probabilities and cost estimates ranging from a best case to a worst case scenario on the outcome measure. (...)

    Mots-clés Pascal : Cirrhose, Foie, Chimioprophylaxie, Péritonite, Bactériose, Infection, Spontané, Antibactérien, Long terme, Analyse coût, Homme, Appareil digestif pathologie, Foie pathologie, Abdomen pathologie

    Mots-clés Pascal anglais : Cirrhosis, Liver, Chemoprophylaxis, Peritonitis, Bacteriosis, Infection, Spontaneous, Antibacterial agent, Long term, Cost analysis, Human, Digestive diseases, Hepatic disease, Abdominal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0492055

    Code Inist : 002B30A01C. Création : 19/02/1999.