Contemporaneous with John Snow's famous study of the 1854 London cholera epidemic were 2 other investigations : a local study of the Broad Street outbreak and an investigation of the entire epidemic, undertaken by England's General Board of Health.
More than a quarter-century prior to Koch's description of Vibrio comma, a Board of Health investigator saw microscopic « vibriones » in the rice-water stools of cholera patients that, in his later life, he concluded had been cholera bacilli.
Although this finding was potential evidence for Snow's view that cholera was due to a contagious and probably live agent transmitted in the water supply, the Board of Health rejected Snow's conclusions.
The Board of Health amassed a huge amount of information which it interpreted as supportive of its conclusion that the epidemic was attributable not so much to water as to air.
Snow, by contrast, systematically tested his hypothesis that cholera was waterborne by exploring evidence that at first glance ran contrary to his expectations.
Snow's success provides support for using a hypothetico-deductive approach in epidemiology, based on tightly focused hypotheses strongly grounded in pathophysiology.
Mots-clés Pascal : Choléra, Bactériose, Infection, Epidémie, Epidémiologie, Histoire, Homme, Angleterre, Grande Bretagne, Royaume Uni, Europe
Mots-clés Pascal anglais : Cholera, Bacteriosis, Infection, Epidemic, Epidemiology, History, Human, England, Great Britain, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0491611
Code Inist : 002B05B02L4. Création : 19/02/1999.