Treatment options in Western hepatocellular carcinoma : a prospective study of 224 patients.
Though hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world, the optimal therapeutic strategy is still poorly defined.
This is mainly due to geographic differences in HCC which may affect the validity of treatment regimens in differents areas of the world.
The aim of the present study was to analyze the natural course of the disease as well as to assess the efficacy of different therapeutical schemes in HCC observed in Ljubljana (Slovenia) and Trieste (Italy), two cities in Western Europe situated close to each other.
During the period from January 1988 to December 1993,224 consecutive patients (132 in Trieste and 92 in Ljubljana) with HCC were enrolled in the study.
Patients were treated with the following 3 schemes : surgery 39 (17.4%), transcatheter chemoembolization (TACE) 116 (51.8%), and no treatment 69 (30.8%). The tumor was classified by Okuda staging and the liver disease by Child-Pugh score.
Patients were followed up for 12-60 months, with an average of 40 months.
The response rate to TACE and recurrence following surgery were evaluated.
Comparative analysis of survival between different treatment groups was performed.
The natural course of the disease, and other characteristics of the HCC, showed a typical Western type of tumor. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Evolution, Stratégie, Traitement, Association, Effet biologique, Grade histologique, Association morbide, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Anatomopathologie
Mots-clés Pascal anglais : Hepatocellular carcinoma, Evolution, Strategy, Treatment, Association, Biological effect, Histological grading, Concomitant disease, Epidemiology, Human, Digestive diseases, Hepatic disease, Malignant tumor, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0491055
Code Inist : 002B13C01. Création : 19/02/1999.