There have been a number of contradictory views concerning the efficacy of mass screening for neuroblastoma.
Three Japanese and one cohort study from Quebec, and three Japanese cross-sectional studies were reviewed.
The four cohort studies revealed that mass screening using high performance liquid chromatography (HPLC) reduced the incidence of this disease by about half in children aged from I to 4 years while little reduction was noted in screening utilizing non-HPLC methods.
There is a large difference in the efficacy of mass screening depending on the method used.
In the three cross-sectional studies, there was no discrimination between screened and unscreened cases, or between subjects screened by HPLC and non-HPLC methods.
The percentage of children in the cross-sectional studies screened by HPLC was low.
Cross-sectional studies seem inappropriate in assessing the effectiveness of current HPLC mass screening.
Mots-clés Pascal : Article synthèse, Dépistage, Prévention, Neuroblastome, Epidémiologie, Japon, Asie, Enfant, Homme, Chromatographie HPLC, Chromatographie phase gazeuse, Spectrométrie masse, Evaluation performance, Technique, Méthodologie, Etude transversale, Système nerveux pathologie, Système nerveux sympathique pathologie, Tumeur maligne
Mots-clés Pascal anglais : Review, Medical screening, Prevention, Neuroblastoma, Epidemiology, Japan, Asia, Child, Human, HPLC chromatography, Gas chromatography, Mass spectrometry, Performance evaluation, Technique, Methodology, Cross sectional study, Nervous system diseases, Autonomic neuropathy, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0489884
Code Inist : 002B17E. Création : 19/02/1999.