Impact of major cardiovascular disease risk factors, particularly in combination, on 22-year mortality in women and men.
The appropriateness of current cardiovascular disease (CVD) risk factor guidelines in women continues to be debated.
To present new data on the appropriateness of current CVD risk factor guidelines, for women and men, from long-term follow-up of a large population sample.
Cardiovascular disease risk factor status according to current clinical guidelines and long-term impact on mortality were determined in 8686 women and 10 503 men aged 40 to 64 years at baseline from the Chicago Heart Association Detection Project in Industry ; average follow-up was 22 years.
At baseline, only 6.6% of women and 4.8% of men had desirable levels for all 3 major risk factors (cholesterol level,<5.20 mmol/L [<200 mg/dL] ; systolic and diastolic blood pressure,<120 and<80 mm Hg, respectively ; and nonsmoking).
With control for age, race, and other risk factors, each major risk factor considered separately was associated with increased risk of death for women and men.
In analyses of combinations of major risk factors, risk increased with number of risk factors.
Relative risks (RRs) associated with any 2 or all 3 risk factors were similar :
for coronary heart disease mortality in women,
RR=5.72 (95% confidence interval [CI], 2.35-13.93), and in men,
RR=5.51 (95% CI, 3.10-9.77) ;
for CVD mortality in women,
RR=4.54 (95% CI, 2.33-8.84), and in men,
RR=4.12 (95% CI, 2.56-6.37) ;
and for all-cause mortality in women,
RR=2.34 (95% CI, 1.73-3. (...)
Mots-clés Pascal : Cardiopathie coronaire, Dépistage, Etude longitudinale, Facteur risque, Etiologie, Homme, Mortalité, Femelle, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Organisation santé
Mots-clés Pascal anglais : Coronary heart disease, Medical screening, Follow up study, Risk factor, Etiology, Human, Mortality, Female, Comparative study, United States, North America, America, Cardiovascular disease, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0488892
Code Inist : 002B12A03. Création : 19/02/1999.