An epidemic of end-stage renal disease (ESRD) is accompanying the rising rates of hypertension, type 2 diabetes and cardiovascular disease among Aborigines in the Northern Territory of Australia.
Incidence rates are now 21 times those of nonAboriginal Australians and are doubling every four years.
We describe the rates and associations of renal disease in one remote community, which has a current ESRD incidence of 2700 per million, and cardiovascular mortality among the highest in Australia.
Methods, Between 1992 and 1995 a community-wide screening program was conducted, in which the urinary albumin/creatinine ratio (ACR) was used as the chief renal disease marker.
More than 90% of the population ages five and older participated.
Results, Albuminuria was evident in early childhood and increased dramatically with age : 26% of adults had microalbuminuria and 24% had overt albuminuria.
All renal failure developed out of a background of overt albuminuria.
ACR was significantly correlated with the presence of scabies at screening. with a history of poststreptococcal glomerulonephritis, which is epidemic and endemic in the community. with increasing body wt, blood pressure, glucose, insulin and lipid levels. and with evidence of heavy drinking.
ACR was also significantly and inversely correlated with birth weight. (...)
Mots-clés Pascal : Protéinurie, Albumine, Insuffisance rénale, Mode de vie, Alimentation, Fonction rénale, Déterminisme génétique, Australie, Océanie, Epidémiologie, Facteur risque, Association morbide, Homme, Aborigène, Appareil urinaire pathologie, Rein pathologie
Mots-clés Pascal anglais : Proteinuria, Albumin, Renal failure, Life habit, Feeding, Renal function, Genetic determinism, Australia, Oceania, Epidemiology, Risk factor, Concomitant disease, Human, Aboriginal, Urinary system disease, Kidney disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0488815
Code Inist : 002B14A05. Création : 19/02/1999.