Cancer risk in patients with cirrhosis could be modified by factors such as changes in hormonal levels, impaired metabolism of carcinogens, or alteration of immunological status.
We investigated the risk of liver and various forms of cancer in patients with cirrhosis in a follow-up study.
We identified 11,605 1-year survivors of cirrhosis from the files of the Danish National Registry of Patients (NRP) from 1977 to 1989.
Occurrence of cancer through 1993 was determined by linkage to the Danish Cancer Registry.
For comparison, the expected number of cancer cases was estimated from national age-sex-and site-specific incidence rates.
Overall, 1,447 cancers were diagnosed among the study subjects, as compared with 708.1 expected, to yield a standardized incidence ratio (SIR) of 2.0 (95% Cl : 1.9 to 2.2).
In all diagnostic subgroups of cirrhosis, the risk of primary liver cancer, mainly hepatocellular carcinoma, was markedly elevated, with 245 observed cases and an overall 36-fold elevated risk (59.9-fold elevated for hepatocellular carcinoma and 10-fold for cholangiocarcinoma).
Substantial and persistent excesses during follow-up were seen for all types of cancer associated with tobacco and alcohol habits (cancer of the lung, larynx, buccal cavity, pharynx, pancreas, urinary bladder, and kidney), while moderate excesses were seen for cancers of the colon and breast.
The latter, however, were not complemented by any decrease in the risk of prostate cancer (SIR : 1. (...)
Mots-clés Pascal : Cirrhose, Foie, Complication, Carcinome, Localisation, Facteur risque, Incidence, Epidémiologie, Homme, Danemark, Europe, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Cirrhosis, Liver, Complication, Carcinoma, Localization, Risk factor, Incidence, Epidemiology, Human, Denmark, Europe, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0483504
Code Inist : 002B13C03. Création : 19/02/1999.